Orotic Acid Induces Hypertension Associated with Impaired Endothelial Nitric Oxide Synthesis
نویسندگان
چکیده
منابع مشابه
Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.
Orotic acid (OA) is an intermediate of pyrimidine nucleotide biosynthesis. Hereditary deficiencies in some enzymes associated with pyrimidine synthesis or the urea cycle induce OA accumulation, resulting in orotic aciduria. A link between patients with orotic aciduria and hypertension has been reported; however, the molecular mechanisms remain elusive. In this study, to elucidate the role of OA...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2015
ISSN: 1096-0929,1096-6080
DOI: 10.1093/toxsci/kfv003